The five-time IPL title winner will begin their battle against the Delhi Capitals at the CCI Stadium in Brabourne on 27 March 2022. This season all matches will be played at the Maharashtra cricket ground. In this tournament, Mumbai Indians will be seen with this key player of the season Rohit Sharma, Suryakumar Yadav, Kieron Pollard, Jasprit Bumrah, Ishan Kishan, Jofra Archer. Where Delhi Capitals is also will be seen with these top star players Rishabh Pant, Axar Patel, Prithvi Shaw, Anrich Nortje, David Warner, Mitchell Marsh, Shardul Thakur, Mustafizur Rahman, KS Bharat, Mandeep Singh, Khaleel Ahmed, Chetan Sakariya, Ripal Patel, Lungi Ngidi
| Date | Match | Time (IST) | Venue |
| March 27, 2022 | Delhi Capitals vs Mumbai Indians | 15:30 | Brabourne – CCI |
| April 2, 2022 | Mumbai Indians vs Rajasthan Royals | 15:30 | DY Patil Stadium |
| April 6, 2022 | Kolkata Knight Riders vs Mumbai Indians | 19:30 | MCA Stadium, Pune |
| April 9, 2022 | Royal Challengers Bangalore vs Mumbai Indians | 19:30 | MCA Stadium, Pune |
| April 13, 2022 | Mumbai Indians vs Punjab Kings | 19:30 | MCA Stadium, Pune |
| April 16, 2022 | Mumbai Indians vs Lucknow Super Giants | 15:30 | Brabourne – CCI |
| April 21, 2022 | Mumbai Indians vs Chennai Super Kings | 19:30 | DY Patil Stadium |
| April 24, 2022 | Lucknow Super Giants vs Mumbai Indians | 19:30 | Wankhede Stadium |
| April 30, 2022 | Rajasthan Royals vs Mumbai Indians | 19:30 | DY Patil Stadium |
| May 6, 2022 | Gujarat Titans vs Mumbai Indians | 19:30 | Brabourne – CCI |
| May 9, 2022 | Mumbai Indians vs Kolkata Knight Riders | 19:30 | DY Patil Stadium |
| May 12, 2022 | Chennai Super Kings vs Mumbai Indians | 19:30 | Wankhede Stadium |
| May 17, 2022 | Mumbai Indians vs Sunrisers Hyderabad | 19:30 | Wankhede Stadium |
| May 21, 2022 | Mumbai Indians vs Delhi Capitals | 19:30 | Wankhede Stadium |
TATA IPL 2022: Mumbai Indians Complete Squad
Rohit Sharma, Suryakumar Yadav, Kieron Pollard, Jasprit Bumrah, Ishan Kishan, Dewald Brevis, Basil Thampi, Murugan Ashwin, Jaydev Udadkat, Mayank Markande, N Tilak Varma, Sanjay Yadav, Jofra Archer, Daniel Sams, Tymal Mills, Tim David, Arshad Khan, Anmolpreet Singh, Ramandeep Singh, Rahul Buddhi, Hrithik Shokeen, Arjun Tendulkar, Fabian Allen, Aryan Juyal, Riley Meredith.