The announcement for player replacements of Royal Challengers Bangalore, Rajasthan Royals, Punjab Kings, and Kolkata Knight Riders
Before resumption of the VIVO IPL 2021 phase 2 in the United Arab Emirates on September 19, Royal Challengers Bangalore (RCB), Rajasthan Royals (RR), Punjab Kings (PBKS), and Kolkata Knight Riders (KKR) declared replacements in their respective squads for the rest of the season.
| Injured / Replaced Player | Team‘s | Replacement Player |
| Adam Zampa | RCB | Wanindu Hasaranga |
| Daniel Sams | RCB | Dushmantha Chameera |
| Kane Richardson | RCB | George Garton |
| Finn Allen | RCB | Tim David |
| Jofra Archer | RR | Glenn Phillips |
| Andrew Tye | RR | Tabraiz Shamsi |
| Riley Meredith | PBKS | Nathan Ellis |
| Jhye Richardson | PBKS | Adil Rashid |
| Pat Cummins | KKR | Tim Southee |
